Supplementary Material for TRPC6 Inhibition in Renal Fibrosis Study

figshare admin karger provides supplementary material for a 2026 study on TRPC6 inhibition in renal tubulointerstitial fibrosis. The 10.6 MB DOCX file contains methodological details and results from experiments using a UUO mouse model and TGF-β1-stimulated HK-2 cells. The data supports findings on the ROS/TXNIP/NLRP3 signaling pathway's role in fibrosis.

Use Cases

• Reviewing experimental methods for a UUO mouse model and HK-2 cell culture based on the detailed description.
• Analyzing protein expression patterns for α-SMA, Fibronectin, TRPC6, and NLRP3 based on IHC and western blotting results mentioned.
• Studying the relationship between reactive oxygen species (ROS) and pyroptosis markers like cGSDMD and IL-1β based on the described pathway.
• Comparing the effects of pharmacological inhibitors SAR7334 and MCC950 on fibrosis markers based on the reported findings.

Strengths

• Dataset is associated with a specific, peer-reviewed research study on a defined molecular pathway.
• The 10.6 MB file size suggests it contains detailed supplementary text and figures.
• It has a clear CC-BY-4.0 license for open reuse.

Limitations

• The dataset is a DOCX document; structured, machine-readable data (e.g., raw measurements) is not confirmed to be included.
• Row count and column-level documentation are unknown, limiting suitability assessment for computational analysis.
• Description metadata is limited; actual data quality and completeness require manual inspection after download.

Provenance

Source

figshare admin karger

Collection Method

Experimental data from a study using UUO mouse models and TGF-β1-stimulated HK-2 cells, with analyses including staining, microscopy, flow cytometry, and western blotting.

Freshness

Last updated 2026-04-21 05:55:37.