Scoping Review of Digital Endpoint Justifications in Parkinson's Disease Trials

45 clinical trials using digital measures as primary or secondary endpoints were analyzed in a scoping review. The qualitative analysis of trial protocols identified a frequent disconnect between regulatory guidelines and research practice regarding the justification of meaningfulness to patients. The dataset supports the need for clearer guidelines and shared examples for developing meaningful digital health measures.

Use Cases

• Analyzing justification patterns for digital endpoints based on qualitative protocol review
• Identifying gaps between regulatory guidelines and research practice based on systematic search results
• Informing guideline development for digital measures based on lessons learned from Parkinson's disease trials

Strengths

• Analysis is based on a systematic search of 45 clinical trials from major registries
• Dataset is openly licensed under CC-BY-4.0, facilitating reuse
• Cross-platform presence on figshare indicates established curation

Limitations

• Column names and row counts are not provided, limiting technical understanding of the data structure
• The dataset consists of supplementary material (DOCX), not a structured data table
• The last update date (2026-03-19) is in the future, indicating a metadata error

Provenance

Source

figshare admin karger

Collection Method

Systematic search of ClinicalTrials.gov and ClinicalTrialsRegister.eu, followed by qualitative analysis of trial protocols

Time Range

null

Freshness

Last updated: 2026-03-19 12:55:21

Geography

null