Venetoclax Efficacy In Chronic Myelomonocytic Leukemia Meta-Analysis

A systematic review and meta-analysis aggregates clinical outcomes for 145 adult patients with chronic myelomonocytic leukemia treated with venetoclax-based regimens. The figshare admin karger published this supplementary material in April 2026, synthesizing data from 17 publications representing nine unique studies. It reports pooled response rates including a 19.1% complete remission rate and a 71.9% overall response rate.

Use Cases

• Analyze the relationship between venetoclax dosing schedules (e.g., CYP3A-guided modifications) and reported response rates like complete remission (CR) and marrow CR (mCR).
• Model the association between specific drug combinations (e.g., VEN with azacitidine or decitabine–cedazuridine) and adverse event rates, such as grade ≥3 neutropenia.
• Investigate temporal patterns in treatment response using the reported typical time to response (within one to two cycles) and durability data.
• Compare pooled efficacy metrics (e.g., the 71.9% overall response rate) against patient cohort characteristics described across the included studies.

Strengths

• Data synthesis from 17 publications following PRISMA 2020 guidelines for systematic review.
• Reports pooled clinical metrics with confidence intervals, such as a 19.1% CR rate (95% CI, 9.4–34.9).
• Focuses on a specific, understudied patient population of 145 CMML patients treated with venetoclax.

Limitations

• Very small dataset scope at 59.2 KB, containing only supplementary document text, not raw patient-level data.
• Limited to aggregated, study-level summary statistics; individual patient records, demographics, and full clinical histories are unavailable.
• Heterogeneous dosing schedules and study designs across the nine source studies may complicate direct comparisons.

Provenance

Source

figshare admin karger

Collection Method

Systematic review and meta-analysis of published clinical studies.

Time Range

Covers studies published up to the date of the meta-analysis.

Freshness

Last updated April 2026.

Geography

Global (studies from unspecified international locations).