Wagner-Nelson Analysis for Gastric Emptying Breath Test Curves

Supplementary material reviews the Wagner-Nelson (WN) method for analyzing 13C breath tests to create time-resolved gastric emptying curves comparable to nuclear scintigraphy. The method addresses limitations of conventional half-emptying time analysis by providing a complete picture of gastric emptying for both solid and liquid meals. The review details the pharmacokinetic assumptions of the one-compartment model and first-order kinetics inherent to the WN analysis.

Use Cases

• Comparing breath test-derived gastric emptying curves to scintigraphic results based on the described WN method.
• Evaluating the impact of one-compartment model assumptions on liquid meal GE estimates as discussed in the review.
• Designing breath test studies with sampling durations exceeding 6 hours to satisfy first-order kinetics requirements.
• Reviewing pharmacokinetic techniques for translating pulmonary 13CO2 elimination into gastric absorption profiles.

Strengths

• Dataset is openly licensed under CC-BY-4.0, permitting reuse and redistribution.
• Cross-platform presence on figshare indicates established sharing and potential for discovery.
• Content is highly specific, focusing on a detailed pharmacokinetic review of a clinical analysis method.

Limitations

• The dataset's structure is unclear; it is listed as a DOCX file with no column information provided.
• The row count is not specified, limiting understanding of the dataset's scale.
• The primary content appears to be a review article's supplementary material rather than a primary data collection.

Provenance

Source

figshare admin karger

Collection Method

Likely authored as supplementary material for a published review article.

Freshness

Last updated on 2026-03-19.