Supplementary Materials for HIV-1 Antiretroviral Therapy Safety Meta-Analysis

A 607.5 KB collection of supplementary materials for a peer-reviewed systematic literature review and network meta-analysis published in the Journal of Comparative Effectiveness Research. The materials, authored by Tristan Curteis, include methodology descriptions and tables comparing the safety of the B/F/TAF regimen against other antiretroviral therapies for treatment-experienced people with HIV-1.

Use Cases

• Reviewing systematic literature review search strategies based on the provided search term tables.
• Assessing study eligibility and risk of bias for meta-analysis based on the PICO framework and quality assessment tables.
• Comparing baseline demographic and clinical characteristics across trials included in the indirect comparisons.
• Examining model selection and input data for the multilevel network meta-regression analysis of safety outcomes.

Strengths

• Materials are peer-reviewed and accompany a published journal article, suggesting academic rigor.
• Includes 14 detailed supplementary tables covering methodology, study characteristics, and input data.
• Analysis adjusted for key covariates including age, sex, race, and CD4 cell count.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 607.5 KB size indicates a limited scope focused on supplementary documentation rather than a primary dataset.

Provenance

Source

figshare, as supplementary materials for a journal article.

Collection Method

Derived from a systematic literature review and multilevel network meta-regression using individual patient data from three Phase III trials and aggregate data from comparator trials.

Time Range

The systematic literature review was conducted in June 2023, with trial data likely preceding that date.

Freshness

Last updated 2026-05-28 12:41:34; freshness should be verified.