Supplementary Materials for CRC Methylation: 259 Tumor Profiles

259 primary colorectal cancer samples profiled using the Illumina EPICv2 array to define methylation signatures of mismatch repair deficiency. The dataset, authored by Rebecca Ward and updated in May 2026, includes supplementary tables with differential methylation statistics and functional enrichment results. Analysis adjusted for tumor purity, MLH1 promoter methylation, CIMP status, and anatomical location.

Use Cases

• Identifying differentially methylated positions between MSI and MSS colorectal cancers based on epigenome-wide profiling.
• Investigating the influence of anatomical location on the tumor methylome, independent of other clinical factors.
• Analyzing functional enrichment of methylation patterns using the provided missMethyl results.
• Studying the CpG Island Methylator Phenotype (CIMP) and its association with MLH1 silencing in a cohort of 259 tumors.

Strengths

• Includes 259 primary colorectal cancer samples, providing a substantial cohort for analysis.
• Uses the Illumina EPICv2 array for epigenome-wide DNA methylation profiling.
• Analysis adjusts for multiple confounders: tumor purity, MLH1 promoter methylation, CIMP status, and anatomical location.
• Supplementary tables contain summary statistics from differential methylation and functional enrichment analyses.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying data tables is unknown, which may limit suitability assessment.
• Data may reflect sample collection bias inherent to the source study on figshare.

Provenance

Source

figshare

Collection Method

Epigenome-wide DNA methylation profiling using the Illumina EPICv2 array on primary tumor samples.

Time Range

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Freshness

Last updated 2026-05-04 14:44:29

Geography

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