Supplementary Table 2: LSD1 and EWS-FLI1 Overlap Genes in Ewing Sarcoma Cell Lines

Rachel D. Dreher created this dataset, last updated on March 18, 2026. It contains lists of genes whose repression by LSD1 overlaps with activation or repression by the EWS-FLI1 fusion protein in three Ewing sarcoma cell lines: A673, CHP-100, and TTC-466. The data is stored in an 18.1 KB XLSX file and shared under a CC-BY-4.0 license.

Use Cases

• Identify coregulated gene sets based on the overlap between LSD1 and EWS-FLI1 targets.
• Validate hypotheses about demethylase-independent roles of LSD1 based on gene repression lists.
• Compare gene regulatory patterns across different Ewing sarcoma cell lines (A673, CHP-100, TTC-466).
• Perform pathway enrichment analysis on the overlapping gene sets.

Strengths

• Data is focused on three specific cell lines (A673, CHP-100, TTC-466), enabling comparative analysis.
• Shared under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.
• File size is 18.1 KB, indicating a compact and likely focused dataset.

Limitations

• Row count is unknown, which may limit suitability assessment for large-scale analyses.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset's 18.1 KB size suggests a very limited scope, potentially containing only summary lists.

Provenance

Source

figshare

Collection Method

Likely derived from experimental analysis of gene expression in Ewing sarcoma cell lines.

Freshness

Last updated 2026-03-18 07:00:10; freshness should be verified.