Supplementary Tables 1-12: Mutation Accumulation and Fitness Data for C. elegans

Supplementary Tables 1-12 provide genomic mutation and fitness assay data from a mutation accumulation experiment in Caenorhabditis elegans. The tables likely contain demographic data, counts of mutations per line, homozygous variant sites, dummy sites for validation, a complete mutation list with annotations, multi-nucleotide variant information, mutation rate estimates, mutational variances, and fitness assay block means. The dataset supports analysis of mutation rates, spectra, biases, and fitness consequences.

Use Cases

• Estimating per-site mutation rates based on Supplementary Table 9 data.
• Analyzing the mutational spectrum and bias from the complete set of mutations in Supplementary Table 7.
• Validating genotyping accuracy using false-negative rates from dummy sites in Supplementary Table 5.
• Investigating fitness effects and epistasis using fitness assay data from Supplementary Tables 11 and 12.
• Studying multi-nucleotide variants (MNVs) using information provided in Supplementary Table 8.

Strengths

• Includes a complete set of mutations with gene name, annotation, and putative impact.
• Provides validation metrics for genotyping accuracy via dummy site analysis.
• Contains fitness assay data with block means and SEM.
• Released under a CC-BY-4.0 license, facilitating reuse.

Limitations

• Column names are not explicitly listed, limiting precise understanding of data structure.
• Row counts are unknown, making it difficult to assess dataset scale.
• The dataset appears to be supplementary material, which may lack standalone documentation.

Provenance

Source

Charles Baer

Collection Method

Likely generated from a mutation accumulation experiment and subsequent genomic and fitness analysis of Caenorhabditis elegans lines.

Freshness

Last updated on 2026-03-20.