pMDRHI2 Plasmid: Fitness and Metabolic Effects in Salmonella Serovars

Integrative transcriptomic and metabolomic data reveals how a large multidrug-resistant plasmid imposes serovar-specific fitness costs in Salmonella. The dataset supports findings that plasmid carriage consistently perturbs chromosomal loci for propanediol and ethanolamine utilization, sulfur, and glycerophospholipid metabolism. Distinct metabolic lesions, such as dysregulated propanoate metabolism or impaired aerobic respiration, are linked to fitness burdens in specific Salmonella backgrounds.

Use Cases

• Identifying host-specific metabolic perturbations based on transcriptomic and metabolomic profiles.
• Modeling the fitness costs of multidrug-resistant plasmid carriage across different bacterial serovars.
• Investigating plasmid-chromosome interactions affecting pathways like propanoate, purine, and sulfur metabolism.
• Correlating differential metabolite expression with transcriptional changes to pinpoint mechanisms of fitness burden.

Strengths

• Dataset size is 44.5 MB, suggesting substantial underlying multi-omics data.
• Integrates two data modalities (transcriptomics and metabolomics) for a coordinated analysis.
• Explicitly compares effects across multiple Salmonella serovars (S. 1,4,[5],12:i:-, S. Indiana, S. Enteritidis).
• Released under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• Column names and row counts are not provided, limiting understanding of data structure.
• The primary data file format is XLSX, which may not be optimal for large-scale computational analysis.
• Metadata regarding data collection methodology and specific sample details is sparse.

Provenance

Source

Author Yuting Su, associated with figshare.

Collection Method

Likely generated from laboratory experiments measuring gene expression and metabolite levels in plasmid-carrying Salmonella strains.

Freshness

Last updated on 2026-03-24.