Tracking Metalloproteins: Arsenic-Binding Protein Data from Lymphoma Cell Lines

Over 200 arsenic-binding proteins were identified in living lymphoma cells using a novel fluorescent probe. The data supports research into the therapeutic mechanism of arsenic trioxide in diffuse large B-cell lymphoma. The dataset was authored by Hongyu Zhao and last updated on June 2, 2026.

Use Cases

• Identify potential therapeutic targets for lymphoma based on arsenic-protein interactions described in the study.
• Analyze subcellular localization patterns of metalloproteins, such as in the nucleus and mitochondria, to understand cell sensitivity.
• Validate the specificity of fluorescent probes for cysteine-rich proteins as described in the methodology.
• Conduct bioinformatics analysis on protein functions related to DNA repair, histone modification, and RNA processing mentioned in the description.

Strengths

• Identifies over 200 specific arsenic-binding proteins.
• Includes data from two distinct lymphoma cell lines (Pfeiffer and OCI-Ly7) for comparison.
• Probe validation showed high selectivity for cysteine-containing proteins like human BIR3 and SlyD.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect experimental bias inherent to the specific cell lines and probe used.

Provenance

Source

figshare, authored by Hongyu Zhao.

Collection Method

Generated via fluorescence-based metalloproteomics using a novel organoarsenic probe (NI-As) in live lymphoma cells.

Freshness

Last updated 2026-06-02 06:29:18; freshness should be verified.