Mecp2-Deficient Mice: Swallow and Respiratory Dysfunction Data

Alyssa Huff's dataset supports a study on dysphagia in Rett Syndrome, using a preclinical mouse model. It contains data on swallow-related submental complex activity, cholinergic immunoreactivity in brainstem nuclei, and respiratory-swallow coordination in Mecp2-deficient mice. The findings provide insight into neuromuscular mechanisms underlying swallowing difficulties in this neurodevelopmental disorder.

Use Cases

• Analyzing swallow-related muscle activity (duration, amplitude) to assess motor unit activation deficits.
• Investigating cholinergic immunoreactivity in hypoglossal, facial, and trigeminal motor nuclei across disease progression.
• Modeling impaired respiratory-swallow coordination by examining transition times and post-swallow rhythm resumption.
• Evaluating the Mecp2-deficient mouse as a preclinical model for upper airway and swallow dysfunction.

Strengths

• Dataset is openly licensed under CC-BY-4.0, facilitating reuse and sharing.
• Data is associated with a specific, peer-reviewed study investigating a clear neuromuscular mechanism.
• Cross-platform presence on figshare suggests the dataset has undergone some level of curation.

Limitations

• Column names and a precise row count are not provided, limiting understanding of the data's structure and scale.
• The dataset's size (53737) is given without units, making its actual volume (e.g., bytes, rows) ambiguous.
• Metadata is incomplete, lacking information on the organization and specific data collection methodology.

Provenance

Source

Alyssa Huff

Collection Method

Likely contains experimental measurements from a controlled laboratory study using Mecp2-deficient and wild-type mice.

Freshness

Last updated on 2026-03-20.