Suspect Lists for Neurotoxicant Screening: Six Chemical Collections

Six distinct chemical lists compiled by researchers at the University of Luxembourg support suspect screening for neurotoxicants. The lists range from 33 to 1,243 entries and include documented neurotoxicants, potential negative controls, and literature-mined candidates. Emma Schymanski led the work, which is described in a paper currently under revision.

Use Cases

• Prioritizing chemicals for developmental neurotoxicity (DNT) testing based on the DNTINVIVO list of 33 compounds.
• Identifying potential negative controls for DNT assays using the DNTPOTNEG list of 41 suggested compounds.
• Broad suspect screening for neurotoxicants using the NEUROTOXINS list of 511 chemicals compiled from public resources.
• Literature-based discovery of neurotoxicity associations via the LITMINEDNEURO list of 1,243 chemicals mined from PubMed.
• Assessing potential human neurotoxicants based on the HUMANNEUROTOX list of 190 chemicals identified from literature.

Strengths

• Provides six specialized lists with distinct purposes, from focused negative controls (41 entries) to broad literature-mined candidates (1,243 entries).
• Includes source data for the NEUROTOXINS list, allowing for traceability and verification.
• Lists are derived from multiple methodologies, including experimental data, literature compilation, and systematic PubMed mining.

Limitations

• Row counts for individual lists are provided, but total dataset size and column-level documentation are unknown.
• The HUMANNEUROTOX list is explicitly described as containing potential, not necessarily active, neurotoxicants.
• Last update date is unknown; freshness unverified.

Provenance

Source

University of Luxembourg

Collection Method

Compiled from experimental data, public resources, and systematic literature mining of PubMed using MeSH terms.