Suspect Screening of Urinary Neurotoxicants in Children with Autistic Spectrum Disorder

A suspect screening study of 768 children (307 with ASD and 461 healthy controls) identified 94 neurotoxicants in urine samples. Guixian Song's work, last updated in May 2026, reports associations between 28 neurotoxicants and ASD diagnosis. The dataset includes compounds such as plasticizers, flame retardants, and insecticides detected at high frequency.

Use Cases

• Identify key neurotoxicant exposures associated with ASD based on conditional logistic regression results.
• Analyze mixed chemical exposure profiles in pediatric populations using the 94 identified neurotoxicants.
• Investigate detection frequencies of specific compound classes like plasticizers and flame retardants mentioned in the description.
• Validate suspect screening methodologies for environmental biomonitoring in clinical cohorts.

Strengths

• Includes data from 768 pediatric participants, providing a substantial sample size for analysis.
• Identifies 94 neurotoxicants with high confidence, covering 7 major chemical classes.
• Reports specific associations for 28 neurotoxicants and identifies 3 key substances (DPG, DPP, mECPP) contributing to ASD risk.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Geographic origin of the study population is not specified, which may limit generalizability.

Provenance

Source

figshare, author Guixian Song

Collection Method

Suspect screening of urine samples from a case-control study.

Freshness

Last updated 2026-05-21 09:22:53; freshness should be verified.