Synergistic Antibacterial Activity of Arginine and Florfenicol Against Resistant E. coli

A 1.7 MB research dataset from figshare, authored by Mingyu Cao and last updated on 2026-04-28. The dataset investigates the combined antibacterial efficacy and mechanism of arginine and florfenicol against resistant Escherichia coli. The study reveals dual mechanisms of action involving metabolic reprogramming and efflux pump inhibition.

Use Cases

• Analyzing synergistic antibacterial effects based on in vivo and in vitro efficacy data mentioned in the description
• Studying mechanisms of antibiotic resistance reversal based on the described inhibition of the arginine succinyl-transferase pathway
• Investigating efflux pump inhibition based on the described reduction in AcrAB-TolC and EmrAB-TolC function
• Researching metabolic reprogramming in bacteria based on the described disruption of fatty acid β-oxidation and free fatty acid accumulation

Strengths

• Dataset is 1.7 MB in size, making it a manageable download.
• The research is licensed under CC-BY-4.0, permitting broad reuse with attribution.
• The description provides a detailed mechanistic explanation of the observed synergistic effects.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset consists of PDF and DOCX files, which may require manual data extraction for computational analysis.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from a study on antibacterial synergy.

Freshness

Last updated 2026-04-28 10:40:03; freshness should be verified.