Cryptotanshinone and Matrine Synergistic Effect on Ovarian Cancer: Preclinical Study Data

1.0 MB of TIF image files from a preclinical study exploring the synergistic therapeutic effect of Cryptotanshinone and Matrine on ovarian cancer cells. The dataset, authored by Haiying Xu and last updated in May 2026, includes results from CCK-8, flow cytometry, Transwell, and qRT-PCR assays, as well as in vivo nude mouse xenograft model data. The research investigates the role of the PI3K/Akt/mTOR pathway in reversing cisplatin resistance.

Use Cases

• Analyzing dose- and time-dependent cell proliferation inhibition based on CCK-8 assay results
• Studying apoptosis induction and migration suppression based on flow cytometry and Transwell assay data
• Investigating drug resistance reversal in cisplatin-resistant cells based on P-gp expression measurements
• Validating pathway inhibition mechanisms based on qRT-PCR data for PI3K/Akt/mTOR genes
• Training models to predict synergistic drug effects based on combined in vitro and in vivo efficacy data

Strengths

• Dataset includes results from multiple experimental assays (CCK-8, flow cytometry, Transwell, qRT-PCR) providing multi-faceted evidence
• Research includes in vivo validation using a nude mouse xenograft model
• Mechanistic investigation includes rescue experiments to confirm the role of the PI3K/Akt/mTOR pathway

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The 1.0 MB size suggests a small dataset, potentially limiting statistical power

Provenance

Source

figshare

Collection Method

Experimental data from cell culture assays (CCK-8, flow cytometry, Transwell, qRT-PCR) and a nude mouse xenograft model.

Freshness

Last updated 2026-05-20 08:00:03; freshness should be verified