Synergistic Toxicity Assessment of Triclosan and Co-occurring Chemicals in Household Clean

A 2026 study by Yongmin Jung evaluates the synergistic toxicity of triclosan and co-occurring chemicals found in household cleaning products. It includes cytotoxicity testing on four human cell lines and mixture modeling to calculate model deviation ratios. The dataset, shared on figshare, provides regulatory insights for consumer chemical management.

Use Cases

• Assessing mixture toxicity risk based on model deviation ratios (MDRs) mentioned in the description
• Cross-referencing synergistic chemical combinations across product categories using the U.S. ChemExpo database
• Integrating bioactivity data from the U.S. EPA's ToxCast database for mechanistic insights
• Evaluating the margin of exposure (MoE) for single chemicals under conventional risk assessment frameworks

Strengths

• Includes cytotoxicity data from four human cell lines (BEAS-2B, HepG2, Jurkat, and SH-SY5Y).
• Identifies eight mixtures with model deviation ratio (MDR) values ≥2, indicating potential synergistic effects.
• Cross-references findings with the U.S. ChemExpo database to show occurrence across multiple consumer product categories.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset's small size (169.4 KB) suggests a limited scope of analysis.

Provenance

Source

figshare

Collection Method

The data was generated through cytotoxicity testing on human cell lines and mixture modeling of concentration–response data.

Freshness

Last updated 2026-05-14 16:35:21; freshness should be verified.