CP38: Fluorescent Cyclic Peptide Structure Targeting Liver Cancer

272.5 KB of molecular structure data for a fluorescent cyclic peptide, CP38, synthesized by Zhiqin Zhang. The peptide selectively targets integrin αvβ3 on hepatocellular carcinoma cells, achieving an 80.5% tumor inhibition rate in vivo. The data was last updated on April 18, 2026.

Use Cases

• Molecular docking studies based on the cyclic peptide structure targeting integrin αvβ3.
• Visualization and analysis of fluorescently labeled peptide-protein interactions.
• Mechanistic studies of apoptosis induction via the PI3K/Akt/mTOR signaling pathway mentioned in the description.
• Transcriptomic data integration to explore regulation of cancer proteoglycan and TNF signaling pathway genes.

Strengths

• Includes specific IC50 cytotoxicity values (6.39 and 10.78 μM) for two HCC cell lines.
• Reports a concrete in vivo tumor inhibition rate of 80.5%.
• Describes a specific molecular target (integrin αvβ3) and mechanism of action.

Limitations

• Dataset is very small (272.5 KB), indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Synthesized and characterized in a research study.

Freshness

Last updated 2026-04-18 13:33:25; freshness should be verified.