CP38: Fluorescent Cyclic Peptide Targeting Integrin αvβ3 for Hepatocellular Carcinoma

Zhiqin Zhang published a dataset on figshare in April 2026 detailing the synthesis and antitumor mechanism of a fluorescent cyclic peptide. The data likely contains molecular structure information, cytotoxicity measurements (IC50 values of 6.39 and 10.78 μM), and transcriptomic analysis results related to cancer pathways. The dataset is provided in PDB format and is 2.1 MB in size.

Use Cases

• Molecular docking studies based on the cyclic peptide structure (CP38)
• Analysis of cytotoxicity profiles based on IC50 values against specific cell lines
• Pathway analysis based on transcriptomic data related to PI3K/Akt/mTOR and TNF signaling

Strengths

• Includes specific IC50 cytotoxicity values (6.39 and 10.78 μM) for two HCC cell lines
• Reports a specific tumor inhibition rate (80.5%) from in vivo studies
• Provides mechanistic insights into apoptosis via suppression of the PI3K/Akt/mTOR pathway

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

Zhiqin Zhang

Collection Method

Synthesized and tested a modified cyclic peptide, followed by mechanistic and transcriptomic analysis.

Freshness

Last updated 2026-04-18 13:33:26; freshness should be verified