CP38: Fluorescent Cyclic Peptide Structure Targeting Liver Cancer

CP38 is a fluorescent RGD-modified cyclic peptide designed to target the αvβ3 integrin on hepatocellular carcinoma cells. The dataset includes a PDB file (555.1 KB) containing the molecular structure of CP38, synthesized and studied by Zhiqin Zhang. The data was last updated on 2026-04-18.

Use Cases

• Analyzing the 3D molecular structure of the cyclic peptide CP38 based on the provided PDB file.
• Studying peptide-integrin binding interactions for targeted drug delivery to cancer cells.
• Validating computational docking models using the experimentally derived structure of the fluorescent probe.
• Investigating structure-activity relationships for peptides designed to suppress the PI3K/Akt/mTOR pathway.

Strengths

• The dataset provides a specific molecular structure (CP38) with demonstrated in vitro cytotoxicity (IC50 values of 6.39 and 10.78 μM).
• The peptide showed a high in vivo tumor inhibition rate of 80.5% in the described study.
• The structure is associated with a clear biological mechanism targeting the αvβ3 integrin and specific signaling pathways.

Limitations

• The dataset is very small (555.1 KB), containing only a single molecular structure file.
• Row count and associated experimental data (e.g., full assay results, transcriptomics) are unknown.
• Column-level documentation is absent; field semantics must be inferred from the PDB format.

Provenance

Source

Zhiqin Zhang via figshare.

Collection Method

The cyclic peptide CP38 was designed, synthesized, and its structure determined, as described in the associated research.

Freshness

Last updated 2026-04-18 13:33:24; freshness should be verified.