GNE-0877: Preclinical PET Radioligand Data for Brain LRRK2 Imaging

A preclinical dataset details the synthesis and evaluation of the carbon-11 labeled radiotracer [11C]GNE-0877 for imaging Leucine-rich repeat kinase 2 (LRRK2) in the brain. The data includes synthesis yields of 12-15%, radiochemical purity ≥97%, and molar activity of 260-330 GBq/μmol, along with brain uptake measurements in rodents and monkeys. The dataset was authored by Susovan Jana and last updated on 2026-05-06.

Use Cases

• Benchmarking radiotracer synthesis protocols based on reported yields and purity metrics.
• Evaluating brain permeability of candidate PET ligands based on measured logD and SUV uptake values.
• Assessing specific binding potential for LRRK2 imaging based on preblocking versus baseline distribution volume (V_T) comparisons.
• Validating preclinical PET imaging models for Parkinson's disease research based on rodent and monkey data.

Strengths

• Reports specific synthesis metrics: isolated yields of ∼12–15%, radiochemical purity ≥97%, and molar activity of 260–330 GBq/μmol.
• Includes concrete physicochemical and pharmacokinetic measurements: measured logD_7.4 of 2.92 and peak brain uptake of ∼4.0 SUV.
• Provides comparative preclinical evaluation data from both rodent and monkey models.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The description indicates an absence of measurable specific binding to LRRK2 in monkey studies, suggesting a key limitation of the candidate tracer.

Provenance

Source

figshare

Collection Method

Experimental synthesis and preclinical evaluation in laboratory studies.

Freshness

Last updated 2026-05-06 19:08:47; freshness should be verified.