Ruthenium Complexes: Synthesis, DNA/BSA Binding, and Cytotoxicity Data

A 44.7 KB dataset from 2026 details four newly synthesized diphosphine ruthenium(II) complexes with NSAID derivatives. Diogo E. L. Carvalho characterized the compounds via NMR, X-ray diffraction, and spectroscopy, and evaluated their interactions with DNA and BSA. Cytotoxicity was tested against breast (MDA-MB-231) and lung (A549) tumor cell lines, with IC50 values ranging from 0.94 to 17.71 μM.

Use Cases

• Compare the cytotoxicity of different ruthenium complexes based on reported IC50 values against MDA-MB-231 and A549 cell lines.
• Analyze structure-activity relationships for ruthenium complexes based on spectroscopic and crystallographic characterization data.
• Investigate potential drug-DNA interactions based on described spectroscopic titration and viscosity measurement results.
• Evaluate protein binding mechanisms based on described interactions with Bovine Serum Albumin (BSA).
• Benchmark new compound selectivity using the reported selectivity indices for specific cell lines.

Strengths

• Includes specific IC50 cytotoxicity values ranging from 0.94–17.71 μM for four distinct complexes.
• Compounds were characterized by multiple techniques including NMR, X-ray diffraction, and cyclic voltammetry.
• Data compares activity against both tumor (MDA-MB-231, A549) and non-tumor (MRC-5) cell lines.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small at 44.7 KB, indicating limited scope.

Provenance

Source

Diogo E. L. Carvalho via figshare

Collection Method

Experimental synthesis and characterization in a laboratory setting.

Freshness

Last updated 2026-04-08 21:45:05; freshness should be verified.