Synthesis and Cytotoxicity of NSAID Ruthenium Complexes for Cancer Research

Four new diphosphine ruthenium(II) complexes with NSAID derivatives were synthesized and characterized. The dataset includes results from DNA/BSA binding studies and cytotoxicity assays against breast and lung tumor cell lines, with IC50 values ranging from 0.94–17.71 μM. The data was published by Diogo E. L. Carvalho on figshare in April 2026.

Use Cases

• Compare the cytotoxicity of novel ruthenium complexes based on reported IC50 values against specific cell lines.
• Investigate structure-activity relationships for metal-NSAID complexes based on the described fenamate ligand variations.
• Study potential drug-DNA and drug-protein interactions based on the spectroscopic and viscosity measurement results.
• Benchmark new anticancer compounds against cisplatin based on the comparative cytotoxicity data provided.

Strengths

• Includes specific IC50 cytotoxicity values (0.94–17.71 μM) for quantitative comparison.
• Compounds were characterized by multiple techniques (NMR, X-ray diffraction, spectroscopy) as stated.
• Data compares activity against three specific cell lines (MDA-MB-231, A549, MRC-5).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (37.8 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Experimental synthesis and laboratory assays as described.

Time Range

The study period is not specified.

Freshness

Last updated 2026-04-08 21:45:04; freshness should be verified.

Geography

The geographical origin of the study is not specified.