Synthesis and Evaluation of Pyridine- and Indazole-Based iNOS Inhibitors for Psoriasis

A computational and experimental study of novel compounds targeting inducible nitric oxide synthase (iNOS) for psoriasis treatment. The dataset, authored by Pasquale Amoia and last updated on 2026-04-22, likely contains results from synthesis, biological evaluation, and computational analysis of these inhibitors. The file is a 56.3 KB XLSX spreadsheet, suggesting a small-scale, structured experimental record.

Use Cases

• Training predictive models for inhibitor potency based on compound structure and experimental results.
• Analyzing structure-activity relationships for iNOS selectivity over endothelial NOS (eNOS).
• Benchmarking new compound effectiveness against known iNOS inhibitors using in vitro and ex vivo cell model data.
• Studying the link between iNOS inhibition and macrophage phenotype shift in psoriatic inflammation.

Strengths

• Includes computational analysis of binding modes for the most promising molecule into iNOS and eNOS.
• Evaluates compounds across multiple in vitro and ex vivo cell models of psoriasis.
• Contains data on metabolic stability and in vivo toxicity for a lead candidate (Compound 10).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset's 56.3 KB size indicates a very limited scope, likely containing summary results rather than raw high-throughput data.

Provenance

Source

figshare

Collection Method

Experimental synthesis, biological evaluation, and computational modeling.

Time Range

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Freshness

Last updated 2026-04-22 17:08:04; freshness should be verified.

Geography

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