Synthesized 2-(2-Pyridyl)Quinolines with Antifungal Activity Assays

A series of 2-(2-pyridyl)quinolines were synthesized via a Povarov reaction under microwave heating. The work by Carmindo Ribeiro Borel reports yields ranging from 30% to 83% and antifungal assays against five Candida species and Cryptococcus neoformans. Some compounds showed high potency, with IC50 values below 1.95 µg/mL against C. tropicalis and C. krusei.

Use Cases

• Training models to predict antifungal activity based on quinoline chemical structures.
• Analyzing the relationship between synthetic yield and reaction conditions for microwave-promoted Povarov reactions.
• Benchmarking the potency of novel compounds against commercial drugs like Nistatin and Miconazole.

Strengths

• Yield data is provided for synthesized compounds, with a reported range of 30% to 83%.
• Antifungal activity is quantified with specific IC50 values, such as <1.95 µg/mL for some compounds.
• The methodology is compared to prior work, noting advantages in scope and a short 2-hour reaction time.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

Carmindo Ribeiro Borel via paperswithcode

Collection Method

Compounds were synthesized via a Povarov reaction and assayed against clinically important yeasts.