Synthesis Data for Carborane-Containing Amino Acid Esters via Alkyne-Insertion Reactions

Experimental synthesis data for carborane-containing esters of natural l-amino acids. The dataset, authored by Xiao-Yu Wang and last updated in April 2026, details the construction of carborane cages using alkyne-insertion reactions. It includes total yields for various products and comparative analysis of 11B NMR spectra to identify optimal reaction conditions.

Use Cases

• Training predictive models for reaction yields based on amino acid side chain and protection group strategies mentioned in the description.
• Analyzing the relationship between solvent coordination properties and carborane cage formation efficiency based on the NMR spectra comparison.
• Benchmarking synthetic pathways for incorporating high-boron content moieties into biological scaffolds as described.
• Studying the chemical stability and derivatization potential of carborane-amino acid conjugates for peptide synthesis.

Strengths

• Yields for final products are quantified, ranging from 42% to 88% over two steps.
• Includes comparative analysis of 11B NMR spectra for multiple solvents to justify the choice of DMF.
• Covers a variety of amino acids with both aliphatic and aromatic side chains.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Laboratory synthesis and spectroscopic analysis.

Time Range

Publication date suggests data from circa 2026.

Freshness

Last updated 2026-04-28 02:30:53; freshness should be verified.

Geography

Organization unknown; likely reflects the author's institutional location.