Clausenamide Isomer Synthesis and Cortical Synaptogenesis Activity

A chemical synthesis and biological evaluation dataset from figshare, authored by Yongyu Ou and last updated on May 6, 2026. The dataset likely contains results from the synthesis of six clausenamide stereoisomers and one analog, and their evaluation for inducing synaptogenesis in primary cortical cultures using high-content imaging.

Use Cases

• Ranking neuroplastogenic potency based on stereoisomer activity levels described in the study.
• Modeling structure-activity relationships for clausenamide analogs based on the synthesized compounds.
• Identifying potential 5-HT2AR partial agonists based on the mechanism suggested for the most active isomer.

Strengths

• Dataset is structured in an XLSX file, suggesting a tabular format for analysis.
• The underlying research includes high-content imaging data from primary cortical cultures.
• License is clearly defined as CC-BY-NC-4.0, specifying permissible use.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Dataset is very small at 14.0 KB, indicating limited scope.

Provenance

Source

figshare, author Yongyu Ou.

Collection Method

Data likely originates from laboratory synthesis and biological assay experiments.

Time Range

null

Freshness

Last updated 2026-05-06 11:33:33; freshness should be verified.

Geography

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