Clausenamide Isomers: Synthesis and Cortical Synaptogenesis Evaluation

A medicinal chemistry study by Yongyu Ou, published on figshare in 2026, reports the synthesis and biological evaluation of clausenamide isomers. The dataset, stored in an XLSX file of 72.7 KB, contains results from high-content imaging of primary cortical cultures. It details the synaptogenic activity of six stereoisomers and one analog, identifying (−)-cis-clausenamide as the most active.

Use Cases

• Ranking neuroplastogen potency based on synaptogenesis assay results described in the study.
• Analyzing structure-activity relationships among clausenamide stereoisomers synthesized via a one-pot method.
• Investigating postsynaptic versus presynaptic effects of plasticity-promoting compounds as mentioned in the description.
• Identifying potential 5-HT2AR partial agonists for cortical neuron growth based on the reported mechanism.

Strengths

• Data is associated with a specific, peer-reviewed synthetic method for creating six stereoisomers and one analog.
• Biological evaluation uses high-content imaging in primary cortical cultures, a relevant model system.
• The dataset identifies a lead compound, (−)-cis-clausenamide, with a proposed mechanism of action as a 5-HT2AR partial agonist.

Limitations

• Row count is unknown, which may limit suitability assessment for statistical analysis.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (72.7 KB), indicating limited scope and likely a focused experimental result set.

Provenance

Source

Yongyu Ou via figshare

Collection Method

Experimental data from chemical synthesis and high-content imaging of primary cortical neuron cultures.

Freshness

Last updated 2026-05-06 11:33:36; freshness should be verified.