Synthesis of Hydrophobic Derivatives of Stilbenes with Improved Permeability and Limited P

Silvia Navarro-Orcajada published data on synthesized hydrophobic derivatives of stilbenes like resveratrol and oxyresveratrol in April 2026. The dataset includes results from chemical and enzymatic synthesis methods, with characterization data for the derivatives. It contains measurements of apparent permeability across Caco-2 intestinal cells and the degree of phase II metabolism (sulfation and glucuronidation).

Use Cases

• Compare synthesis efficiency between chemical and enzymatic methods based on the described experimental results.
• Model the relationship between hydrophobicity and apparent permeability across Caco-2 cells based on the characterization data.
• Analyze the reduction in phase II metabolism (sulfation/glucuronidation) for hydrophobic derivatives compared to original stilbenes.
• Identify promising stilbene derivative candidates for oral administration in functional foods based on the combined permeability and metabolism data.

Strengths

• Dataset is 3.7 MB, indicating a focused and likely manageable size for analysis.
• Includes comparative data on two synthesis methods (chemical vs. enzymatic) and their efficiency.
• Contains experimental results for two key bioavailability metrics: permeability and phase II metabolism.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Data generated from laboratory synthesis and characterization experiments.

Freshness

Last updated 2026-04-15 19:11:15; freshness should be verified.