Preclinical and Clinical Data for 68Ga-Labeled c-Met PET Probes

Preclinical investigations and pilot clinical imaging studies for a series of peptide-derived, c-Met-targeted PET probes labeled with Gallium-68. It reports synthesis details, in vitro/in vivo stability (>90%), and clinical results including tumor-to-lung ratios and correlation with c-Met expression (R=0.71). The dataset is 265.7 KB in size.

Use Cases

• Analyze the correlation between tumor-to-lung ratio (TLR) data and c-Met expression levels (R=0.71) from clinical imaging.
• Compare the in vivo performance and stability (>90%) metrics across the different PEG linker variants (n = 2, 4, 6) of the probes.
• Evaluate pharmacokinetic profiles using data on urinary system excretion and organ uptake patterns from the pilot clinical study.
• Assess synthesis quality using reported metrics for radiochemical yield (>80%) and purity (>95%).

Strengths

• Reports specific quantitative results from clinical evaluation, including a tumor-to-lung ratio (TLR) of 4.87 and a correlation coefficient (R=0.71) with c-Met expression.
• Includes synthesis and stability metrics for three probe variants, with radiochemical yield >80%, purity >95%, and in vitro/vivo stability >90%.
• Contains data spanning from preclinical development (affinity, specificity) to a pilot clinical safety and imaging study in human participants.

Limitations

• The dataset is very small in scale (265.7 KB), indicating limited raw data or primary measurements, likely consisting of summary results and figures.
• Clinical data is from a pilot study, implying a small sample size which limits the statistical power and generalizability of the findings.
• The specific data structure (rows, columns) and sample data are unavailable, making direct computational analysis difficult without further clarification.

Provenance

Source

figshare, authored by Yinting Hu.

Collection Method

Experimental research data from the synthesis, preclinical testing, and a pilot clinical imaging study of novel radiotracers.

Freshness

Last updated in March 2026.