c-Met-Targeted PET Probe Data: Radiochemical Yields and Tumor Uptake Ratios

Featuring results from the synthesis, preclinical investigation, and pilot clinical imaging of three peptide-derived, c-Met-targeted PET probes labeled with Gallium-68. It reports radiochemical yields over 80%, purity over 95%, in vivo stability over 90%, and tumor-to-lung ratios from a clinical study. The data was authored by Yinting Hu and shared under a CC BY-NC 4.0 license.

Use Cases

• Analyze the correlation between tumor-to-lung ratio (TLR) and c-Met expression levels (R = 0.71) from clinical imaging.
• Compare the in vivo performance and stability (>90%) metrics across the three synthesized probes (NOTA-PEGn-Glc-MetP, n=2,4,6).
• Evaluate radiochemical yield (>80%) and purity (>95%) data for the synthesis of Ga-68-labeled peptide probes.

Strengths

• Reports specific quantitative metrics including radiochemical yield (>80%), purity (>95%), and in vivo stability (>90%).
• Includes clinical results with a calculated tumor-to-lung ratio (TLR: 4.87) and its correlation to c-Met expression (R=0.71, P=0.034).
• Data is recent, last updated in March 2026.

Limitations

• The dataset is very small (2.8 KB), indicating limited scope and likely a summary of key results rather than raw experimental data.
• Column structure and sample data are unavailable, limiting direct analytical utility without further context.
• License is CC BY-NC 4.0, restricting commercial use.

Provenance

Source

figshare, authored by Yinting Hu.

Collection Method

Experimental data from the synthesis, preclinical testing, and a pilot clinical imaging study of novel PET probes.

Freshness

2026-03-20