Polymethine-Modified Cy3 Fluorophores: A Library for Viscosity Sensing

A library of symmetric and unsymmetric trimethine cyanine (Cy3) fluorophores was generated through a three-step synthetic strategy. The dataset includes compounds with absorption maxima between 550 and 590 nm and emission maxima between 560 and 650 nm, with some showing up to a 20-fold brightness enhancement in high-viscosity environments. Authored by Mohan Kodisana and last updated in April 2026, this work provides data for fine-tuning photophysical properties.

Use Cases

• Developing viscosity-sensitive molecular rotors based on the described up to 20-fold brightness enhancement in high-viscosity environments.
• Fine-tuning photophysical properties for bioimaging based on the systematic variation of aliphatic, aromatic, and electron-withdrawing substituents.
• Validating computational chemistry models using the experimental absorption and emission data and accompanying TD-DFT calculations.
• Designing fluorophores for bioconjugation applications based on the synthetic strategy's reported compatibility with a broad range of indolenines.

Strengths

• Includes compounds with measured absorption maxima between 550 and 590 nm and emission maxima between 560 and 650 nm.
• Documents a three-step, high-yielding synthetic strategy for accessing a structurally diverse library.
• Reports specific performance metrics, such as Stokes shifts up to 100 nm and brightness enhancements up to 20-fold in high viscosity.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 24.8 KB, indicating a limited scope.

Provenance

Source

figshare

Collection Method

Synthetic chemistry and photophysical characterization, as described in the associated research.

Freshness

Last updated 2026-04-08 20:05:33; freshness should be verified.