PFAS Systematic Evidence Map: Mammalian Bioassay and Epidemiological Studies

A 2026 systematic evidence map compiled by Avanti V. Shirke, summarizing available human health hazard data for per- and polyfluoroalkyl substances (PFAS). The work inventories 347 mammalian bioassay and 44 epidemiological studies meeting specific criteria, covering 99 and 30 individual PFAS respectively. Underlying data are publicly available for download.

Use Cases

• Identify PFAS with available mammalian bioassay or epidemiological evidence based on the systematic literature inventory.
• Analyze health systems studied across PFAS chemicals based on the 15 and 16 health systems covered by the epidemiological and bioassay evidence.
• Assess data scarcity for PFAS chemicals based on the finding that only 1.4% of the ~14,735 identified PFAS have any relevant health data.

Strengths

• Systematic methodology combining manual review and machine learning for literature screening.
• Covers a large chemical space, referencing ~14,735 PFAS identified by the EPA's CCTE.
• Includes a diverse array of supplemental content such as mechanistic data and exposure-only studies.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The data reflects a specific literature search scope; coverage of non-English or non-indexed sources may be limited.

Provenance

Source

Literature searches from peer-reviewed and gray literature sources.

Collection Method

Systematic evidence map methods utilizing a combination of manual review and machine learning software.

Time Range

Studies identified up to the date of the literature searches (not specified).

Freshness

Last updated 2026-04-20 00:04:09

Geography

Not explicitly stated; likely global given the scope of PFAS research.