Systematic Optimization of Meta-Halogenated ¹⁸F‑Benzylguanidine Derivatives for

A 2026 study by Yue Zhou investigated five systematically modified 18F-labeled benzylguanidine derivatives for PET imaging of cardiac sympathetic innervation. The dataset likely contains results from in vitro and in vivo evaluations, including biodistribution in mice and PET imaging in pigs. The most promising candidate, 18F-FBr, demonstrated high myocardial uptake and NET-specific binding.

Use Cases

• Comparing the biological properties of different meta-halogenated benzylguanidine derivatives based on the systematic substitution described.
• Evaluating myocardial uptake and retention metrics for novel PET radiotracers based on the reported biodistribution and SUV data.
• Validating NET-specific binding of cardiac imaging agents based on the desipramine blocking studies mentioned.

Strengths

• Includes specific quantitative results, such as myocardial uptake of 12.26 %ID/g in mice and SUVmean > 4 in pigs.
• Describes a systematic experimental approach with five derivatives and confirmed NET-specific binding.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (254.0 B), indicating limited scope.

Provenance

Source

figshare, author Yue Zhou.

Collection Method

Likely contains synthesized results from preclinical radiolabeling, biodistribution, and PET imaging studies.

Freshness

Last updated 2026-04-24 11:35:57; freshness should be verified.