Table 1_1H-MRS brain metabolites as biomarkers of high-altitude hypobaric hypoxia followin

A pilot study by Young Woo Park, uploaded on 2026-05-14, investigates neurochemical biomarkers in mice exposed to high-altitude hypobaric hypoxia and mild traumatic brain injury. The dataset likely contains longitudinal metabolite measurements from the frontal cortex, hippocampus, and cerebellum, collected via 1H-MRS over a 14-week experimental period. It includes results on metabolites such as myo-inositol, total choline, total N-acetylaspartate, and total creatine.

Use Cases

• [Identify metabolic biomarkers of high-altitude adaptation] based on longitudinal 1H-MRS measurements of brain metabolites
• [Model the neurochemical impact of mild traumatic brain injury] based on metabolite changes post-closed head injury
• [Assess metabolic recovery differences between high-altitude and sea-level adapted subjects] based on comparisons of metabolite levels like tNAA and tCho

Strengths

• Longitudinal design with measurements at weeks 0, 4, 12, and 14 provides a time-series view of metabolic changes
• Multi-region brain analysis includes data from the frontal cortex, hippocampi, and cerebellum
• The study uses a controlled animal model with specific exposure conditions: simulated high altitude (5,000 m) for 12 weeks

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is small (85.9 KB), indicating limited scope and likely a summary of results rather than raw spectral data

Provenance

Source

Young Woo Park via figshare

Collection Method

In vivo 1H-MRS spectra collected at 7 T from male C57BL/6J mice exposed to simulated high altitude or sea level, followed by a closed head injury model of mild TBI.

Time Range

Experimental timeline spans 14 weeks, including a 12-week adaptation period and 2-week post-injury monitoring.

Freshness

Last updated 2026-05-14 05:44:53; freshness should be verified

Geography

Laboratory study; geographic origin of data collection is unknown.