TNBC Immune Microenvironment Data: 25HC Regulation of Macrophage Polarization

11.8 KB Excel file from a study investigating the triple-negative breast cancer immune microenvironment. The research, authored by Hongmei Zheng and shared on figshare, identified the oxysterol metabolite 25-hydroxycholesterol as a key regulator of CD163+ macrophage polarization via the interferon pathway. The dataset was last updated on 2026-05-28.

Use Cases

• Validate bioinformatic predictions about macrophage regulation based on the described interferon regulatory factor 7–cholesterol-25-hydroxylase–25HC axis.
• Analyze links between lipid metabolism and immune cell function in cancer based on the integrated metabolic and immune contexture mentioned.
• Investigate potential therapeutic targets for triple-negative breast cancer based on the identified immunometabolic mechanisms.

Strengths

• Data is associated with a specific, peer-reviewed research methodology combining multiplex fluorescence immunohistochemistry, bioinformatics, and in vitro/in vivo validation.
• Dataset is openly licensed under CC-BY-4.0, facilitating reuse and redistribution.

Limitations

• Row count and column-level documentation are unknown, which limits suitability assessment.
• The dataset is very small (11.8 KB), suggesting it may contain summary or supplementary results rather than raw experimental data.

Provenance

Source

figshare, authored by Hongmei Zheng.

Collection Method

Generated from multiplex fluorescence immunohistochemistry and bioinformatic analyses, validated with cellular assays and mouse models.

Time Range

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Freshness

Last updated 2026-05-28 04:43:31; freshness should be verified.

Geography

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