NK Cell-Related Gene Signature for Prostate Cancer Diagnosis

A nine-gene diagnostic signature for prostate cancer, derived from integrated scRNA-seq and bulk RNA-seq analyses. The signature includes HSPD1, HSPE1, CLU, KIT, LAPTM4A, SLC18A2, TUBA4A, VWA5A, and ZFP36L1, and was validated in independent datasets with an AUC >0.8. The dataset, authored by Zhengjun Chen and last updated in June 2026, includes functional validation results for the KIT gene.

Use Cases

• Developing diagnostic models for prostate cancer based on NK cell-related gene expression.
• Identifying potential drug sensitivity compounds based on the expression profiles of nine specific genes.
• Validating gene expression signatures in independent prostate cancer tissue samples.
• Investigating the functional role of KIT in NK cell cytotoxicity against prostate cancer cells.

Strengths

• The diagnostic signature was validated in independent datasets and demonstrated strong predictive ability (AUC >0.8).
• Functional validation of the KIT gene was performed through experiments on prostate cancer cells.
• The dataset is licensed under CC-BY-4.0, allowing for open sharing and reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a 16.1 MB DOCX document, which may not be a standard format for structured data analysis.

Provenance

Source

figshare

Collection Method

Derived from integrated scRNA-seq and bulk RNA-seq analyses, with validation using tumor and adjacent normal tissue samples.

Freshness

Last updated 2026-06-03 05:42:59; freshness should be verified.