HIV-Associated Cognitive Impairment and Treatment Response: Multimodal Neuroimaging Data

A neuroimaging dataset from a study applying a multimodal integrative model to associate baseline MR metrics with cognitive performance in persons with HIV. The dataset, created by Xing Qiu and last updated in April 2026, includes features such as volumetric data, cerebral blood flow, cerebrovascular reactivity, and diffusion MRI data from cortical, subcortical, and white matter brain regions. The study tracked longitudinal changes over a 12-week treatment period with combination antiretroviral therapy.

Use Cases

• Modeling associations between baseline neuroimaging features and longitudinal cognitive change based on the described integrative framework.
• Comparing the predictive performance of multimodal versus unimodal models for cognitive trajectories using the described metrics.
• Identifying key brain region predictors (e.g., frontal pole, amygdala) for cognitive outcomes based on the feature selection results mentioned.
• Developing penalized regression models for 'large p, small n' neuroimaging data as described in the methodology.

Strengths

• Data integrates multiple complementary imaging modalities (volumetric, cerebral blood flow, cerebrovascular reactivity, diffusion MRI).
• The associated study framework is designed for interpretability in 'large p, small n' data scenarios.
• Dataset is licensed under CC-BY-4.0, allowing for open reuse and modification.

Limitations

• Row count and specific column definitions are unknown, limiting suitability assessment.
• The dataset is very small (21.2 KB), suggesting limited scope or a summary table rather than raw data.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

figshare, author Xing Qiu.

Collection Method

Data was generated from a clinical study applying MR neuroimaging to persons with HIV and healthy controls.

Time Range

Study involved a longitudinal observation period of 12 weeks.

Freshness

Last updated 2026-04-13 05:47:46.

Geography

Geographic coverage is not specified in the provided metadata.