eoPRED: Placental DNA Methylation Scores Associated with Early-Onset Preeclampsia

493 placental samples with DNA methylation data and histopathologic characterization form the basis of this dataset. Hannah J. Illing published the eoPRED tool, a DNA methylation-based score that correlates with maternal vascular malperfusion pathology severity. The score was higher in placentas from pregnancies with early-onset preeclampsia and showed a correlation with pathology grade independent of the disease.

Use Cases

• Validate DNA methylation biomarkers for placental dysfunction based on the described eoPRED score.
• Investigate associations between epigenetic signatures and specific placental pathology classes like maternal vascular malperfusion.
• Identify potential placental dysfunction in datasets lacking pathology information based on the DNA methylation score.

Strengths

• Includes 493 placental samples with paired DNA methylation and histopathologic data.
• Focuses on a specific, severe maternal hypertensive disorder (early-onset preeclampsia) with 7 cases analyzed.
• Demonstrates a statistically significant correlation (R=0.34, p<0.01) between the eoPRED score and pathology grade.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (20.5 KB), suggesting limited scope or summary data.

Provenance

Source

figshare

Collection Method

Infinium EPICv1.0 DNA methylation data and histopathologic characterization by a placental pathologist.

Freshness

Last updated 2026-06-04 22:01:26; freshness should be verified.