Geraniin and Ulcerative Colitis: Multi-Omics and In Vivo Analysis Results

Chang Cheng's dataset contains results from a preclinical investigation into geraniin's effects on ulcerative colitis in mice. The data includes multi-omics analysis targeting 27 genes and in vivo experimental results from DSS-induced UC mice treated with geraniin at 30 and 60 mg/kg doses. It was last updated on May 13, 2026.

Use Cases

• Validate gene expression changes in inflammatory pathways like IL-17 and TNF signaling based on differential gene analysis.
• Investigate macrophage and neutrophil subpopulation targeting based on single-cell AUCell score enrichment.
• Correlate in vivo treatment outcomes like Disease Activity Index scores and colon length with molecular markers.
• Explore protein-protein interaction networks involving the 42-gene key subnetwork identified by MCODE analysis.

Strengths

• Integrated analysis combines multi-omics data (337 UC-related genes) with in vivo experimental results.
• In vivo validation includes specific geraniin dosage levels (30 mg/kg and 60 mg/kg) and multiple assessment methods.
• Data is openly shared under a CC-BY-4.0 license, facilitating reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (68.8 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Generated from a preclinical study using database screening, transcriptomic analysis from GEO datasets, and in vivo mouse experiments.

Freshness

Last updated 2026-05-13 04:48:13; freshness should be verified.