Proteome-Wide Atlas of Humoral Immunity to Mycobacterium Tuberculosis

An atlas of antibody protein binding across the spectrum of Mycobacterium tuberculosis infection, created by Mehak Z. Khan and last updated in June 2026. The data maps antibody specificities across individuals with varying Mtb exposure, including latent infection, active TB, and non-human primate models. It points to promising Mtb protein candidates for antibody-based TB interventions.

Use Cases

• Identify promising TB vaccine antigens based on antibody binding patterns.
• Compare humoral immune responses across different stages of Mtb infection.
• Investigate the functional role of antibodies targeting surface and secreted proteins.
• Guide the design of antibody-based interventions for tuberculosis.

Strengths

• Data is proteome-wide, mapping antibody specificities across the entire Mtb proteome.
• Covers a spectrum of disease states, including latent infection, active TB, and non-human primate models.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

figshare

Collection Method

Generated using a proteome-wide Mtb microarray.

Freshness

Last updated 2026-06-03 04:51:01; freshness should be verified.