Rabbit Model of VREF Bacteremia and Sepsis with mAb Treatment Outcomes

A rabbit model of acute bacteremia caused by vancomycin-resistant Enterococcus faecium (VREF), with mortality rates exceeding 60% in untreated animals. The dataset likely contains results from 20 New Zealand White rabbits divided into control, infected, and monoclonal antibody-treated groups, measuring clinical signs, bacterial loads, and cytokine levels. Authored by Karen Flores-Moreno and shared on figshare in April 2026 under a CC-BY-4.0 license.

Use Cases

• Modeling clinical outcomes of VREF sepsis based on weight loss, fever, and mortality data
• Evaluating monoclonal antibody efficacy based on comparisons of bacterial loads and histopathological damage across organs
• Analyzing systemic inflammatory response based on plasma cytokine levels (IL-6, IL-8, IL 10)
• Benchmarking organ-specific infection severity based on bacterial load quantification in kidneys, lungs, spleen, heart, and liver

Strengths

• Data is derived from a controlled, reproducible animal model using 20 New Zealand White rabbits
• Includes multi-modal measurements: clinical outcomes, bacterial loads in five organs, and plasma cytokine profiling
• Explicitly compares three experimental groups (control, infected untreated, infected treated) for clear therapeutic evaluation

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is very small (15.5 KB), indicating limited scope and likely summary-level data

Provenance

Source

figshare

Collection Method

Experimental study establishing a rabbit model of VREF infection, with animals intravenously challenged with 1 × 10^9 CFU/g of VREF strain E155.

Time Range

The experimental time frame is not specified.

Freshness

Last updated 2026-04-16 05:25:57; freshness should be verified

Geography

The geographic origin of the study is not specified.