Genetic Studies of Treatment-Resistant Schizophrenia: A Scoping Review

A scoping review synthesizing evidence on the genetic architecture of treatment-resistant schizophrenia (TRS). The review includes 102 studies identified via a systematic PubMed search up to March 2025, following PRISMA-ScR guidelines. It was authored by Urmi Das and last updated in May 2026.

Use Cases

• Surveying the landscape of genetic studies on treatment-resistant schizophrenia based on the synthesized review of 102 papers.
• Identifying knowledge gaps and heterogeneous definitions of TRS based on the review's findings.
• Analyzing associations between polygenic risk scores, rare variants, and TRS based on the extracted genetic findings.
• Planning future research requiring harmonized criteria and diverse cohorts based on the review's conclusions.

Strengths

• Includes 102 studies, providing a broad survey of the field.
• Follows PRISMA-ScR guidelines for systematic scoping reviews.
• Explicitly covers genetic findings spanning common variants, rare variants, copy number variants, and functional genomics.

Limitations

• The dataset is small (42.2 KB), indicating a summary table rather than raw genetic data.
• Row and column counts are unknown, limiting assessment of the table's structure and granularity.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

figshare, author Urmi Das

Collection Method

Systematic literature search in PubMed following PRISMA-ScR guidelines.

Time Range

Literature search conducted up to March 2025.

Freshness

Last updated 2026-05-19 22:01:31

Geography

Studies predominately included participants of European genetic ancestry.