Scoping Review of Imatinib-Induced Testicular Toxicity and Male Fertility Impairment

A scoping review synthesizing preclinical and clinical evidence on the gonadotoxic effects of the drug imatinib in males. The review, authored by Xia Ji and published on figshare in 2026, includes 20 studies published between 2003 and 2025. It examines mechanisms, dose- and age-dependent susceptibility, and the reversibility of testicular injury.

Use Cases

• Summarizing evidence on drug-induced reproductive toxicity based on the review's synthesis of 20 studies.
• Informing clinical guidelines for fertility preservation based on the review's findings on dose- and age-dependent risks.
• Identifying research gaps in male gonadotoxicity based on the scoping review methodology and conclusions.

Strengths

• Follows PRISMA-ScR guidelines for scoping reviews, indicating a structured methodology.
• Synthesizes evidence from 20 studies published over a 22-year period (2003-2025).
• Explicitly addresses dose- and age-dependent effects and reversibility, key clinical concerns.

Limitations

• The dataset is a 13.7 KB document; its scope is limited to a textual summary rather than raw data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

Literature review conducted in PubMed, Scopus, and Web of Science.

Time Range

Studies published between 2003 and 2025.

Freshness

Last updated 2026-05-14 14:14:07; freshness should be verified.