Murine Model Immune Response Data for Varicella-Zoster Virus mRNA Vaccine
by Wenyu Cheng·Updated 3mo ago
1.4 MB1files
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Description
Immunogenicity data from a study evaluating a novel VZV mRNA vaccine candidate (KH014) in BALB/c mice. The dataset contains results from ELISA, microneutralization, ELISpot, and flow cytometry assays comparing single-dose, two-dose, and heterologous prime-boost regimens against a licensed vaccine. It documents humoral and cellular immune responses, including T-cell persistence for at least 10 weeks.
Use Cases
Compare VZV-specific antibody titers from ELISA and microneutralization assays across different vaccine regimens (single-dose KH014, two-dose KH014, Shingrix).
Analyze antigen-specific CD4+ and CD8+ T-cell response data from ELISpot and intracellular cytokine staining to assess cellular immunity durability.
Model the relationship between immunization regimen and memory T-cell phenotypes (central vs. effector) derived from flow cytometry data.
Evaluate the immunogenicity enhancement of a heterologous prime-boost strategy (KH014 prime/Shingrix boost) using polyfunctional T-cell response metrics.
Strengths
Data originates from a controlled murine model study with direct comparison to a licensed vaccine (Shingrix).
Includes longitudinal immune response tracking, with T-cell responses monitored for at least 10 weeks post-immunization.
Assesses multiple immunization regimens: single-dose, two-dose, and heterologous prime-boost.
Limitations
The dataset is contained within a 1.4 MB DOCX file, indicating it is likely a summary table or manuscript figure rather than a raw, machine-readable data table.
Data is derived solely from a murine model (BALB/c mice), limiting direct extrapolation to human immune responses.
Sample size, specific row/column counts, and raw numerical data are not provided in the input, restricting analytical scope.
Provenance
Source
Wenyu Cheng via figshare.
Collection Method
Experimental data generated from immunogenicity evaluations in a murine model, including ELISA, microneutralization, ELISpot, and flow cytometry.
Freshness
Last updated March 2026.
Primary data is embedded in a DOCX document (1.4 MB); extraction and digitization of tabular data from figures or text may be required for computational analysis. Licensed under CC BY 4.0.