Gut Microbiota and Blood Metabolite Associations with Sepsis from Mendelian Randomization

Table 1 from a bioinformatics study by Yanhuo Zhang, last updated March 2026, presents results from a two-sample Mendelian randomization analysis. The data identifies 23 gut microbiota taxa and 169 blood metabolites associated with sepsis, with 15 metabolites mediating causal relationships. The 4.8 MB Excel file is licensed under CC-BY-4.0 and was shared on figshare.

Use Cases

• Validate causal links between specific gut microbiota taxa and sepsis based on the 23 identified associations.
• Investigate metabolic mediation pathways using the 15 identified mediator metabolites.
• Prioritize therapeutic targets based on the 131 predicted molecular targets and network analysis results.
• Replicate or extend Mendelian randomization analyses for sepsis using the provided genetic association data.

Strengths

• Identifies a specific number of associations: 23 gut microbiota taxa and 169 blood metabolites linked to sepsis.
• Reports mediation proportions for 15 metabolites, ranging from 3.70% to 13.70%.
• Data is associated with a published bioinformatics study integrating multiple analysis methods.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect methodological bias inherent to the specific Mendelian randomization and bioinformatics pipeline used.

Provenance

Source

Yanhuo Zhang via figshare.

Collection Method

Generated from a two-sample Mendelian randomization analysis combined with bioinformatics and pharmacodynamic experiments.

Freshness

Last updated 2026-03-18 07:35:36; freshness should be verified.