Vitamin Biomarker Risk Score for 90-Day Stroke Outcome in a 655-Patient Cohort

655 acute ischemic stroke patients from Huludao Central Hospital, admitted between November 2024 and July 2025, were retrospectively analyzed. The dataset includes demographic, clinical, and serum vitamin biomarker levels (vitamins D, E, A, K1, B12, folate, homocysteine) used to develop a nomogram for predicting 3-month functional outcome. The model was developed and internally validated by Yang Xu, with results published in May 2026.

Use Cases

• Developing a predictive model for 90-day functional outcome after ischemic stroke based on serum vitamin biomarker levels.
• Analyzing associations between specific vitamins (D, E, A, K1, B12, folate) and homocysteine with stroke recovery.
• Benchmarking the performance of a biomarker-based model against a clinical baseline model using AUC metrics.
• Conducting internal validation of a clinical prediction tool using bootstrap resampling methods.

Strengths

• Includes data from 655 patients with a mean age of 66.84 years and admission NIHSS score of 3.98.
• Model demonstrated good discrimination with an AUC of 0.880 in the test set.
• Multivariable analysis adjusted for numerous clinical confounders including age, sex, BMI, and vascular risk factors.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• Data is from a single-center retrospective study with internal validation only, as noted by the author.
• The dataset is very small at 45.9 KB, indicating limited scope, likely containing summary results rather than raw patient records.

Provenance

Source

Huludao Central Hospital, author Yang Xu.

Collection Method

Retrospective cohort study of consecutive patients.

Time Range

Patient admissions from November 2024 to July 2025.

Freshness

Last updated 2026-05-29 04:45:04.

Geography

Single-center study from Huludao, China.