Systematic Review and Meta-Analysis of Corticosteroids in Pediatric Orbital Cellulitis

A systematic review and meta-analysis of six studies evaluating adjunctive systemic corticosteroids in children hospitalized with orbital cellulitis. The analysis includes data from 11,803 pediatric patients and was conducted by Emily S. Acker, with results published in 2026. It compares outcomes such as length of stay, surgery, and readmission between corticosteroid-plus-antibiotic and antibiotic-only treatments.

Use Cases

• Assessing the association between corticosteroid use and hospital length of stay based on the reported mean difference.
• Evaluating the risk of surgical intervention linked to corticosteroid treatment based on the reported relative risk.
• Analyzing the relationship between corticosteroid use and pediatric intensive care unit admission based on the reported risk ratio.
• Investigating the impact of adjunctive corticosteroids on 30-day readmission rates based on the pooled results.

Strengths

• Includes data from 11,803 pediatric patients across six studies, providing a substantial sample size.
• Reports specific quantitative outcomes, including mean difference for length of stay and relative risks for surgery, PICU admission, and readmission.
• Follows PRISMA guidelines for systematic review and is registered with PROSPERO (CRD420251102999).

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The certainty of evidence is described as low to moderate, largely due to the observational nature of most included studies.
• The dataset is very small (17.3 KB), indicating limited raw data scope.

Provenance

Source

Emily S. Acker via figshare

Collection Method

PRISMA-compliant systematic review and meta-analysis pooling data from eligible studies.

Time Range

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Freshness

Last updated 2026-04-20 05:23:36; freshness should be verified.

Geography

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