Aging T Cell Proteomics Data on PDHK1 Expression and Glycolytic Activity

Proteomic analysis identified pyruvate dehydrogenase kinase 1 (PDHK1) as significantly downregulated in aged murine T cells. The 915.0 KB dataset, published by Rajkumar S. Kalra under CC-BY-4.0, supports findings that PDHK1 loss impairs glycolysis and T cell receptor responses. Data last updated on 2026-05-11.

Use Cases

• Analyze the relationship between PDHK1 expression and T cell activation based on proteomic measurements.
• Investigate age-associated defects in glycolytic activity following T cell receptor stimulation.
• Model the impact of PDHK1 knockout or overexpression on T cell effector molecule expression.
• Compare protein expression profiles between young and aged CD4+ and CD8+ T cells.

Strengths

• Dataset is based on data-independent acquisition (DIA) mass spectrometry, a quantitative proteomic method.
• Findings are validated across both CD4+ and CD8+ T cell subsets and different activation states.
• License is CC-BY-4.0, permitting broad reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is limited to murine T cells, which may not directly translate to human immunology.

Provenance

Source

figshare

Collection Method

Data-independent acquisition (DIA) mass spectrometry-based proteomic analysis of murine T cells.

Freshness

Last updated 2026-05-11 14:41:02; freshness should be verified.