AGR2 and Macrophage Polarization: Pan-Cancer Analysis and Experimental Data

A research document analyzing the role of the AGR2 protein in tumor progression and macrophage polarization. The study uses pan-cancer expression data from TCGA, in vitro experiments with recombinant AGR2, and in vivo models of melanoma and lung carcinoma. The document was authored by Naming Wu and last updated on March 18, 2026.

Use Cases

• Correlating AGR2 expression levels with patient prognosis based on TCGA pan-cancer analysis
• Investigating mechanisms of macrophage M2 polarization based on in vitro experiments with recombinant AGR2
• Studying the CD98hc-xCT/p-ERK signaling pathway in tumor-associated macrophages
• Analyzing immune cell infiltration and T-cell function suppression in tumor models

Strengths

• Analysis is based on pan-cancer data from TCGA, a major public repository
• Includes validation from in vitro experiments and two in vivo tumor models (B16-F10 melanoma and Lewis lung carcinoma)
• Released under a permissive CC-BY-4.0 license

Limitations

• The primary data file is a 951.4 KB DOCX document, which is a small text file; underlying raw experimental or analysis datasets are not directly provided
• Column-level documentation for any associated data is absent; data structure must be inferred from the manuscript
• Row count for any underlying datasets is unknown, limiting suitability assessment for computational analysis

Provenance

Source

figshare

Collection Method

The description indicates data was gathered from TCGA database analysis, clinical specimen examination, and laboratory experiments (in vitro and in vivo).

Freshness

Last updated 2026-03-18 07:35:34