Skin Microbiome Alterations in HIV Infection with Pruritus

23.5 KB of data from a study comparing skin microbiomes and plasma cytokines in three groups: HIV infection with pruritus, HIV infection without pruritus, and healthy controls. Swabs from four body sites were analyzed using 16S rRNA amplification, and plasma cytokines were measured via ELISA. The dataset, authored by Xue Ding and last updated in April 2026, is shared under a CC-BY-4.0 license.

Use Cases

• Identify microbial signatures of pruritus based on the depletion of Cutibacterium and Burkholderia-Caballeronia-Paraburkholderia.
• Analyze correlations between opportunistic pathogens like Prevotella and Leptotrichia and pro-inflammatory cytokine IL-6 levels.
• Train classification models to distinguish HIV-associated pruritus using the key microbial features identified by Random Forest analysis.
• Investigate the relationship between protective commensal loss and anti-inflammatory cytokine IL-10 levels.

Strengths

• Includes data from four distinct body sites per participant, allowing for site-specific microbiome analysis.
• Integrates two data types: 16S rRNA sequencing results for microbiome composition and ELISA results for plasma cytokines IL-6 and IL-10.
• Uses a comparative study design with three defined groups (HIV with pruritus, HIV without pruritus, healthy controls).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 23.5 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Skin swabs analyzed via 16S rRNA amplification; plasma cytokines detected by enzyme-linked immunosorbent assay (ELISA).

Freshness

Last updated 2026-04-22 05:49:01; freshness should be verified.